Portal:CPTAC
From WikiPathways
CPTAC Pathways
Welcome to the CPTAC Pathway PortalThis portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC). The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public. The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011. | 
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Cancer Hallmark Categories
| Sustaining proliferative signaling
Hepatocyte growth factor receptor signaling (Homo sapiens) Image does not exist Hepatocyte growth factor receptor signaling | Evading growth suppressors
Tumor suppressor activity of SMARCB1 (Homo sapiens) Image does not exist Tumor suppressor activity of SMARCB1 | Activating invasion and metastasis
TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition (Homo sapiens) Image does not exist TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition |
| Enabling replicative immortality
Wnt/beta-catenin signaling in leukemia (Homo sapiens) Image does not exist Wnt/beta-catenin signaling in leukemia | Inducing angiogenesis
PDGF pathway (Homo sapiens) Image does not exist PDGF pathway | Resisting cell death
Apoptosis (Homo sapiens) Image does not exist Apoptosis |
| Deregulating cellular energetics
Hereditary leiomyomatosis and renal cell carcinoma pathway (Homo sapiens) Image does not exist Hereditary leiomyomatosis and renal cell carcinoma pathway | Genome instability and mutation
DNA IR-damage and cellular response via ATR (Homo sapiens) Image does not exist DNA IR-damage and cellular response via ATR | Tumor promoting inflammation
IL6 signaling (Homo sapiens) Image does not exist IL6 signaling |
| Avoiding immune destruction
Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens) Image does not exist Altered glycosylation of MUC1 in tumor microenvironment | Therapeutics
MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement (Homo sapiens) Image does not exist MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement |
Featured Pathways
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Image does not exist PDGFR-beta pathway Zhang, et al. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer |
| View featured pathways |
| List of all pathways for this portal |
Pathway Curation
On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.
Getting Started
- Introduction to WikiPathways (slides)
- WikiPathways Overview or New Contributor Quickstart
- General help pages
- CPTAC Workshop Exercises
Resources
- Learn more about CPTAC
- Pathway analysis
- Cytoscape and the WikiPathways app
- PathVisio and the WikiPathways plugin
Curation projects
- Curating Hallmark Pathways -- How to
- Example: construction of Pathways in Renal Cancer
- Contact Alex Pico if interested in curating, adding or using CPTAC pathways, [email protected]
