Portal:CPTAC/Hallmark/Invasion

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E-cadherin was well established as an antagonist of invasion and metastasis. The frequently observed downregulation and occasional mutational inactivation of E-cadherin in human carcinomas provided strong support for its role as a key suppressor of this hallmark capability. Additionally, expression of genes encoding other cell-to-cell and cell-to-ECM adhesion molecules is demonstrably altered in some highly aggressive carcinomas, with those favoring cytostasis typically being downregulated. Conversely, adhesion molecules normally associated with the cell migrations that occur during embryogenesis and inflammation are often upregulated. (Adapted from Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011)

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