Portal:CPTAC/Hallmark/immortality

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Cancer cells require unlimited replicative potential in order to generate macroscopic tumors. Telomeres protecting the ends of chromosomes normally shorten with successive cell generations, but cancer cells have higher levels of telomerase, an enzyme that adds length to telomeres. (Adapted from Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011)

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