Portal:CPTAC/Hallmarks

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Sustaining proliferative signaling

PDGFR-beta pathway (Homo sapiens)

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PDGFR-beta pathway
Evading growth suppressors

TGF-beta receptor signaling (Homo sapiens)

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TGF-beta receptor signaling
Activating invasion and metastasis

TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition (Homo sapiens)

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TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition
Enabling replicative immortality

Wnt/beta-catenin signaling in leukemia (Homo sapiens)

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Wnt/beta-catenin signaling in leukemia
Inducing angiogenesis

PDGF pathway (Homo sapiens)

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PDGF pathway
Resisting cell death

TP53 network (Homo sapiens)

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TP53 network
Deregulating cellular energetics

Fatty acid beta-oxidation (Homo sapiens)

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Fatty acid beta-oxidation
Genome instability and mutation

DNA IR-double strand breaks and cellular response via ATM (Homo sapiens)

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DNA IR-double strand breaks and cellular response via ATM
Tumor promoting inflammation

IL1 signaling (Homo sapiens)

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IL1 signaling
Avoiding immune destruction

Interferon type I signaling (Homo sapiens)

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Interferon type I signaling
Therapeutics

lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

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lncRNA-mediated mechanisms of therapeutic resistance
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