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- Pathway:WP4415 ... cers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts an ... ... umans, the pathways do show points of significant divergence. Notably, the human genome encodes three Ci homologues, GLI1, 2 and 3 that each play slightly ...388 KB (46676 words) - 16:11, 25 January 2021
- Pathway:WP1822 ... is bound to the TATA box present in many promoters. There are at least 23 human TAF proteins that have been identified. Many of these are ubiquitously ex ... ... ven to this conserved transcription factor family. There are at least two human CSL homologues, which are now named RBPJ and RBPJL. <br><br>I ...726 KB (85515 words) - 12:37, 22 May 2021
- Pathway:WP2738 ... ascade in humans are unknown.<p>Four additional processes related to human Hippo signaling, although incompletely characterized, have been described ... ... m a complex. This interaction has not been experimentally characterized in human cells but is inferred from properties of the homologous mouse proteins. Th ...93 KB (11670 words) - 16:49, 25 January 2021
- Pathway:WP2586 ... yl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes.</bp:TITLE> ... hlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.</bp:TITLE>158 KB (18160 words) - 20:59, 5 May 2023
- Pathway:WP2720 ... oliferation and differentiation, and it is implicated in a great number of human diseases.<br>TGF beta (TGFB1) is secreted as a homodimer, and as suc ... <Comment Source="Reactome">In humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, ...522 KB (58148 words) - 17:03, 25 January 2021
- Pathway:WP2751 ... d activate transcription of CEBPA, one of the key transcription factors in adipogenesis. A current hypothesis posits a self-reinforcing loop that maintains PPARG ... ... ymerase II complex. Multiple analyses of immunoprecipitated complexes from human cells (HeLa cells) detects 31 subunits. Other complexes with fewer subunit ...162 KB (18197 words) - 12:48, 9 May 2021
- Pathway:WP3226 ... of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture.</bp:TITLE> ... yl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes.</bp:TITLE>164 KB (18902 words) - 10:59, 21 May 2021
- Pathway:WP3599 ... "http://pathvisio.org/GPML/2013a" Name="Transcription factor regulation in adipogenesis" Version="20151120" Organism="Homo sapiens"> ... nt Source="WikiPathways-description">The transcription factors involved in adipogenesis are shown in the current pathway. Adipogensis is the biological proces of ...53 KB (5297 words) - 23:13, 15 August 2019
- Pathway:WP4085 ... achidonic acid (ARA) signaling pathway. It was discovered by searching the human EST database for homology to existing CYPs and subsequent cloning and expr ... ... ally formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to ...791 KB (84485 words) - 15:39, 9 October 2020
- Pathway:WP3839 ... ment Source="Reactome">Although the enzyme catalysing retinal reduction in human enterocytes is not identified, the best candidate is retinol dehydrogenase ... ... ferator activated receptor gamma (PPAR-gamma). Ablation of RETSAT inhibits adipogenesis but this block was not overcome by the product of RETSAT enzymatic activit ...239 KB (26373 words) - 16:15, 25 January 2021
- Pathway:WP4105 <Comment Source="Reactome">In human hematopoietic progenitors, RUNX1 and its partner CBFB are up-regulated at ... ... from the distal P1 promoter (Sroczynska et al. 2009, Bee et al. 2010). In human T cells, RUNX1 is preferentially transcribed from P1 throughout developmen ...490 KB (57231 words) - 16:12, 25 January 2021
- Pathway:WP4114 ... rtant, as imbalances in lipid metabolism can have serious consequences for human health. Free fatty acids can act as detergents to disrupt membranes so the ... ... rtant, as imbalances in lipid metabolism can have serious consequences for human health. Free fatty acids can act as detergents to disrupt membranes so the ...176 KB (19430 words) - 16:25, 25 January 2021
- Pathway:WP4414 ... ucocorticoid receptor response element (GRE), which is also present in the human promoter (Zhang et al. 2012).<br>NKX3-2 (BAPX1), required for embryo ... ... targeting it for proteasome-mediated degradation. HIVEP3 overexpression in human embryonic kidney 293T cells leads to a dose-dependent decrease in RUNX2 pr ...234 KB (25282 words) - 17:05, 25 January 2021
- Pathway:WP4421 ... t;i>Rdh1</i> (human ortholog RDH16) and <i>Rdh10</i> (human ortholog RDH10), have been knocked out in mice and display RA-associated p ... ... o the reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL). Human retinol dehydrogenase 13 (RDH13) is located on the outer surface of the mi ...171 KB (19408 words) - 01:58, 22 May 2024
- Pathway:WP4844 ... c switch. When it is on, adipogenesis is repressed --> in first days of adipogenesis- differentiation is blocked when it is off, adipogenesis is initiated.98 KB (10203 words) - 05:39, 21 July 2024
- Pathway:WP4879 <Comment>MIR33b is highly induced upon differentiation of human preadipocytes + SREBP1</Comment> <Comment>negative regulator of adipogenesis, despite being highly upregulated during221 KB (24354 words) - 05:44, 21 July 2024
- Pathway:WP4949 ... atatype="http://www.w3.org/2001/XMLSchema#string">The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor ph ... ... l peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.</bp:TITLE>159 KB (17133 words) - 16:18, 26 July 2024
- Pathway:WP5001 ... ls (inferred from mouse). Unlike the promoter of the mouse Cebpa gene, the human CEBPA promoter does not bind CEBPA and autoregulation of CEBPA occurs indi ... ... lls, KLF5 is required for granulocyte differentiation and in some cases of human acute myelogenous leukemia (AML), KLF5 is silenced by hypermethylation (Di ...183 KB (21015 words) - 16:44, 25 January 2021
- Pathway:WP5098 ... /22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human Disease Ontology</bp:Ontology> ... .org/2001/XMLSchema#string">Regulated production of the chemokine CCL28 in human colon epithelium.</bp:TITLE>132 KB (14993 words) - 03:58, 7 August 2024
- Pathway:WP5102 <Label TextLabel="Adipogenesis Adipocyte survival" GraphId="ff46f"> ... new molecules: integrative biology and therapeutic targets in accelerated human ageing.</bp:TITLE>73 KB (7831 words) - 09:41, 7 August 2022
