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• Pathway:WP4415
  ... cers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts an ... ... associated with a slow growth, but at the same time it results in reduced apoptosis and increases resistance of cells to genotoxic and endoplasmic reticulum s ...
  388 KB (46676 words) - 16:11, 25 January 2021
• Pathway:WP138
  ... nder certain conditions. Various regulators that regulate androgen induced apoptosis include BRCA1 and Smad3 and Akt. Mutation in AR are also known to be assoc ... <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  103 KB (10259 words) - 00:53, 30 October 2025
• Pathway:WP314
  ... t Source="WikiPathways-description">This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. ... <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP7 | caspase 7 apoptosis-related cysteine p..." />
  63 KB (5810 words) - 14:33, 22 November 2025
• Pathway:WP231
  ... ation of NF-κB, which exerts antiapoptotic effects. Cellular inhibitor of apoptosis, BIRC2 and BIRC3 has E3-ubiquitin ligase activity and functionally interac ... ... lation with TNF alpha induces the activation and phosphorylation of JNK in human RASFs, HeLa, endometric stromal cells, HUVECs, dendritic cells and 3T3-L1 ...
  125 KB (12512 words) - 07:33, 5 March 2025
• Pathway:WP188
  <Comment>X-linked inhibitor of apoptosis, also known as Birc4, Api3, riap3</Comment> <Label TextLabel="Apoptosis" GraphId="c47">
  131 KB (12447 words) - 10:24, 16 May 2021
• Pathway:WP376
  <Comment>Mapping based on name of ortholog human gene.</Comment> <Comment>Identifier based on similar name for ortholog human gene</Comment>
  288 KB (39057 words) - 12:35, 31 July 2025
• Pathway:WP152
  ... from rps6ka3# to rps6ka3a - the original UniGene ID Dr.21039 links now to human olfactory receptor</Comment> <Label TextLabel="Mitochondrial Pathway of Apoptosis" GraphId="dbb">
  73 KB (6820 words) - 15:02, 27 May 2021
• Pathway:WP15
  ... g">Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.</bp:TITLE> ... atatype="http://www.w3.org/2001/XMLSchema#string">Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.</bp:TITLE>
  604 KB (70685 words) - 07:08, 10 December 2025
• Pathway:WP367
  ... f:datatype="http://www.w3.org/2001/XMLSchema#string">Germline survival and apoptosis.</bp:TITLE> ... Schema#string">A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans.</bp:TITLE>
  29 KB (3652 words) - 12:14, 3 September 2024
• Pathway:WP176
  <Label TextLabel="Apoptosis" GraphId="e1188"> ... :datatype="http://www.w3.org/2001/XMLSchema#string">Membrane topography of human phosphatidylethanolamine N-methyltransferase.</bp:TITLE>
  612 KB (76224 words) - 05:41, 9 December 2025
• Pathway:WP706
  ... s are predicted to be transcriptionally regulated by a common factor, FEV (human orthologue of PET-1). PET-1 knock-out results in up to a 90% loss of serot ... <Comment Source="GenMAPP remarks">KAP0 HUMAN</Comment>
  545 KB (55738 words) - 05:27, 10 September 2025
• Pathway:WP5443
  <DataNode TextLabel="Apoptosis" GraphId="f33b1" Type="Pathway"> ... g">Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons.</bp:TITLE>
  45 KB (4880 words) - 18:58, 19 July 2025
• Pathway:WP722
  <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ... <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ...
  709 KB (96633 words) - 09:44, 19 November 2025
• Pathway:WP734
  ... n activation of the transcriptional factor CREB ( 44 ) as well as HSP27 in human cells and HSP25 in bovine and murine cells ( 4 , 17 ). 16189297 The insensitivity of the high-affinity agonist binding of the human 5-HT 7 receptor to the destabilizing effect of guanine nucleotides (Albert ...
  180 KB (24396 words) - 14:50, 2 March 2025
• Pathway:WP732
  ... d 5-HT2B-receptor protect cardiomyocytes against serum deprivation-induced apoptosis as manifested by DNA fragmentation, nuclear chromatin condensation, and TU ... ... ng">RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.</bp:TITLE>
  183 KB (24554 words) - 14:50, 2 March 2025
• Pathway:WP897
  ... nder certain conditions. Various regulators that regulate androgen induced apoptosis include BRCA1 and Smad3 and Akt. Mutation in AR are also known to be assoc ... <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  108 KB (10840 words) - 23:28, 28 February 2025
• Pathway:WP902
  <Comment Source="GenMAPP remarks">Converted to human by GenMAPP.org.</Comment> ... t Source="WikiPathways-description">This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress.
  61 KB (5540 words) - 23:27, 28 February 2025
• Pathway:WP1014
  ... nder certain conditions. Various regulators that regulate androgen induced apoptosis include BRCA1 and Smad3 and Akt. Mutation in AR are also known to be assoc ... <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  118 KB (11968 words) - 07:43, 2 March 2025
• Pathway:WP1019
  <Comment Source="GenMAPP remarks">Converted to human by GenMAPP.org.</Comment> ... t Source="WikiPathways-description">This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress.
  70 KB (6595 words) - 07:52, 2 March 2025
• Pathway:WP1047
  ... ation of NF-κB, which exerts antiapoptotic effects. Cellular inhibitor of apoptosis, BIRC2 and BIRC3 has E3-ubiquitin ligase activity and functionally interac ... ... <Comment>Stimulation with TNF alpha induces the phosphorylation of ERK in human RASFs, HeLa cells, eosinophils, endometriotic stromal tissue, 3T3-L1 cells ...
  143 KB (14447 words) - 18:56, 3 March 2025

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