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• Pathway:WP4415
  ... cers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts an ... ... umans, the pathways do show points of significant divergence. Notably, the human genome encodes three Ci homologues, GLI1, 2 and 3 that each play slightly ...
  388 KB (46676 words) - 16:11, 25 January 2021
• Pathway:WP61
  <Comment>DLL4 interacts with NOTCH1 in co-culture of human primary macrophages and a mouse stromal cell.</Comment>
  80 KB (8212 words) - 01:29, 22 May 2024
• Pathway:WP127
  ... <Comment>IL-5 stimulation leads to tyrosine phosphorylation of PTPN11 in human eosinophils.</Comment> <Comment>IL-5 stimulation leads to autophosphorylation of p45 MEK in human eosinophils.</Comment>
  70 KB (7129 words) - 11:14, 9 August 2024
• Pathway:WP364
  ... hosphorylation and activation of ERK1 in AF-10 B cell line,LNCaP cells and human granulosa cells,ES cell line,E14TG2a respectively.</Comment> ... hosphorylation and activation of ERK2 in AF-10 B cell line,LNCaP cells and human granulosa cells,ES cell line,E14TG2a respectively.</Comment>
  89 KB (8699 words) - 20:01, 27 July 2024
• Pathway:WP231
  ... lation with TNF alpha induces the activation and phosphorylation of JNK in human RASFs, HeLa, endometric stromal cells, HUVECs, dendritic cells and 3T3-L1 ... ... <Comment>Stimulation with TNF alpha induces the phosphorylation of ERK in human RASFs, HeLa cells, eosinophils, endometriotic stromal tissue, 3T3-L1 cells ...
  125 KB (12512 words) - 01:30, 22 May 2024
• Pathway:WP493
  <Comment Source="GenMAPP remarks">Converted to human by GenMAPP.org</Comment>
  127 KB (12340 words) - 10:32, 23 May 2021
• Pathway:WP376
  <Comment>Mapping based on name of ortholog human gene.</Comment> <Comment>Identifier based on similar name for ortholog human gene</Comment>
  288 KB (39057 words) - 11:06, 9 May 2021
• Pathway:WP69
  ... >TCR stimulation induces the phosphorylation of MEK2 in DP thymocytes, the human Jurkat T leukemia cell line (clone E6-1)and jurkat T cells.</Comment> ... stimulation induces the phosphorylation of LCK at Tyrosine 192 and 505 in human Jurkat T cell lines and T lymphoblastoid cell line, H9 (TCR/CD3 cross link ...
  111 KB (11290 words) - 01:47, 7 August 2024
• Pathway:WP15
  ... g">Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.</bp:TITLE> ... atatype="http://www.w3.org/2001/XMLSchema#string">Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.</bp:TITLE>
  620 KB (72894 words) - 06:55, 12 January 2023
• Pathway:WP176
  ... :datatype="http://www.w3.org/2001/XMLSchema#string">Membrane topography of human phosphatidylethanolamine N-methyltransferase.</bp:TITLE> ... string">Relationship of plasma folic acid and status of DNA methylation in human gastric cancer.</bp:TITLE>
  614 KB (76290 words) - 12:12, 30 June 2024
• Pathway:WP722
  <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ... <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ...
  709 KB (96586 words) - 14:31, 9 March 2023
• Pathway:WP968
  ... on leads to tyrosine phosphorylation of Raf-1 and subsequent activation in human eosinophils.</Comment> ... ment>IL-5 stimulation leads to phosphorylation at tyrosine 705 of STAT3 in human eosinophils.</Comment>
  89 KB (8939 words) - 11:15, 21 May 2021
• Pathway:WP976
  ... hosphorylation and activation of ERK1 in AF-10 B cell line,LNCaP cells and human granulosa cells,ES cell line,E14TG2a respectively.</Comment> ... hosphorylation and activation of ERK2 in AF-10 B cell line,LNCaP cells and human granulosa cells,ES cell line,E14TG2a respectively.</Comment>
  102 KB (10131 words) - 20:19, 17 March 2021
• Pathway:WP1011
  ... >TCR stimulation induces the phosphorylation of MEK2 in DP thymocytes, the human Jurkat T leukemia cell line (clone E6-1)and jurkat T cells.</Comment> ... stimulation induces the phosphorylation of LCK at Tyrosine 192 and 505 in human Jurkat T cell lines and T lymphoblastoid cell line, H9 (TCR/CD3 cross link ...
  128 KB (13229 words) - 11:43, 21 May 2021
• Pathway:WP1047
  ... <Comment>Stimulation with TNF alpha induces the phosphorylation of ERK in human RASFs, HeLa cells, eosinophils, endometriotic stromal tissue, 3T3-L1 cells ... ... <Comment>Stimulation with TNF-alpha induces the phosphorylation of ERK in human RASFs, endometrial stromal cells, dendritic cells, B16/F10.9 and 3T3-L1 ad ...
  143 KB (14447 words) - 10:15, 7 May 2021
• Pathway:WP1064
  <Comment>DLL4 interacts with NOTCH1 in co-culture of human primary macrophages and a mouse stromal cell.</Comment>
  93 KB (9673 words) - 11:22, 21 May 2021
• Pathway:WP1075
  ... tp://www.w3.org/2001/XMLSchema#string">Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C ... ... g">Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.</bp:TITLE>
  619 KB (77474 words) - 06:15, 20 July 2024
• Pathway:WP1533
  ... tatype="http://www.w3.org/2001/XMLSchema#string">cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a ... ... tiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.</bp:TITLE>
  546 KB (68191 words) - 11:47, 2 August 2024
• Pathway:WP1763
  ... full name: alpha thalassemia/mental retardation syndrome X-linked homolog (human)</Comment> ... ing">Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells</bp:TITLE>
  741 KB (73570 words) - 19:29, 26 April 2023
• Pathway:WP1775
  ... t;50% of human tumors. Thus, the importance of the checkpoint pathways to human biology is clear. ... complex has also been found to interact with base excision repair factors human DNA polymerase beta, flap endonuclease FEN1, and the S. pombe MutY homolog ...
  618 KB (67890 words) - 12:00, 22 May 2021

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