Portal:CPTAC/Hallmarks

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Sustaining proliferative signaling

Hepatocyte growth factor receptor signaling (Homo sapiens)

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Hepatocyte growth factor receptor signaling
Evading growth suppressors

Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (Homo sapiens)

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Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
Activating invasion and metastasis

Integrin-mediated cell adhesion (Homo sapiens)

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Integrin-mediated cell adhesion
Enabling replicative immortality

Regulation of Wnt / B-catenin signaling by small molecule compounds (Homo sapiens)

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Regulation of Wnt / B-catenin signaling by small molecule compounds
Inducing angiogenesis

Hedgehog signaling (Homo sapiens)

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Hedgehog signaling
Resisting cell death

miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)

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miRNA regulation of p53 pathway in prostate cancer
Deregulating cellular energetics

Glycolysis and gluconeogenesis (Homo sapiens)

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Glycolysis and gluconeogenesis
Genome instability and mutation

DNA damage response (only ATM dependent) (Homo sapiens)

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DNA damage response (only ATM dependent)
Tumor promoting inflammation

Cytokines and inflammatory response (Homo sapiens)

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Cytokines and inflammatory response
Avoiding immune destruction

Type II interferon signaling (Homo sapiens)

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Type II interferon signaling
Therapeutics

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression (Homo sapiens)

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression
4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression