Portal:COVID-19/FeaturedPathways

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== SARS-CoV-2 Pathways ==
== SARS-CoV-2 Pathways ==
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{| style="margin: 10px; background-color:#8DA6A6"
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{| style="margin: 10px; background-color:#009A79 "
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP4846|250px||SARS-CoV-2 and COVID-19 Pathway}}
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP4846|250px||SARS-CoV-2 and COVID-19 Pathway}}
Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.
Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.
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{| style="margin: 10px; background-color:#009A79 "
|width=100px|{{#pwImage:Pathway:WP4876|250px||Activation of NLRP3 Inflammasome by SARS-CoV-2}}
|width=100px|{{#pwImage:Pathway:WP4876|250px||Activation of NLRP3 Inflammasome by SARS-CoV-2}}
Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.
Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.
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{| style="margin: 10px; background-color:#009A79 "
|width=100px|{{#pwImage:Pathway:WP4904|250px||LDLRAD4 pathway in COVID-19}}
|width=100px|{{#pwImage:Pathway:WP4904|250px||LDLRAD4 pathway in COVID-19}}
|width=100px|{{#pwImage:Pathway:WP4936|250px||Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)}}
|width=100px|{{#pwImage:Pathway:WP4936|250px||Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)}}
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== Other coronaviruses: MERS, SARS-CoV, etc ==
== Other coronaviruses: MERS, SARS-CoV, etc ==
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{| style="margin: 10px; background-color:#8DA6A6"
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{| style="margin: 10px; background-color:#009A79 "
|width=100px|{{#pwImage:Pathway:WP4853|250px||Coronavirus lipid metabolism}}
|width=100px|{{#pwImage:Pathway:WP4853|250px||Coronavirus lipid metabolism}}
Lipid metabolism alternations that are related to infection by the corona virus.
Lipid metabolism alternations that are related to infection by the corona virus.
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{| style="margin: 10px; background-color:#009A79 "
|width=100px|{{#pwImage:Pathway:WP4861|250px||ER stress response in Coronavirus infection}}
|width=100px|{{#pwImage:Pathway:WP4861|250px||ER stress response in Coronavirus infection}}
|width=100px|{{#pwImage:Pathway:WP4799|250px||Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein}}
|width=100px|{{#pwImage:Pathway:WP4799|250px||Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein}}
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== More about ACE2 ==
== More about ACE2 ==
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{| style="margin: 10px; background-color:#009A79 "
|width=100px|{{#pwImage:Pathway:WP554|250px||ACE Inhibitor Pathway}}
|width=100px|{{#pwImage:Pathway:WP554|250px||ACE Inhibitor Pathway}}
|width=100px|{{#pwImage:Pathway:WP2729|250px||Metabolism of Angiotensinogen to Angiotensins (Reactome)}}
|width=100px|{{#pwImage:Pathway:WP2729|250px||Metabolism of Angiotensinogen to Angiotensins (Reactome)}}

Revision as of 14:43, 11 September 2020

SARS-CoV-2 Pathways

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SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

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Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with multiple members of the Cullin 2 ubiquitin ligase complex.

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Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

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COVID-19, thrombosis and anticoagulation
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Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

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SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target
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COVID-19 AOP

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

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nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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LDLRAD4 pathway in COVID-19
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Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)

Other coronaviruses: MERS, SARS-CoV, etc

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Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

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Host-pathogen interaction of human corona viruses - autophagy
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Host-pathogen interaction of human corona viruses - apoptosis
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SARS coronavirus and innate immunity
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ER stress response in Coronavirus infection
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Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
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Host-pathogen interaction of human corona viruses - MAPK signaling
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Host-pathogen interaction of human corona viruses - Interferon induction

More about ACE2

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ACE Inhibitor Pathway
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Metabolism of Angiotensinogen to Angiotensins (Reactome)

List of featured pathways:

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