Portal:COVID-19/FeaturedPathways

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SARS-CoV-2 Pathways

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SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

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Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with multiple members of the Cullin 2 ubiquitin ligase complex.

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Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

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COVID-19, thrombosis and anticoagulation
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Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

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SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target
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COVID-19 AOP

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

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nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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LDLRAD4 pathway in COVID-19
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Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)
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STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens)
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RAS and Bradykinin pathways in COVID-19 (Homo sapiens)
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nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
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SARS-CoV-2 mitochondrial interactions
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SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response
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A draft map of SARS-COV-2 signaling pathway map (Homo sapiens)
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Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens)

Other coronaviruses: MERS, SARS-CoV, etc

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Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

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Host-pathogen interaction of human corona viruses - autophagy
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Host-pathogen interaction of human corona viruses - apoptosis
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SARS coronavirus and innate immunity
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ER stress response in Coronavirus infection
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Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
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Host-pathogen interaction of human corona viruses - MAPK signaling
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Host-pathogen interaction of human corona viruses - Interferon induction
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Deregulation of the Renin Angiotensin system by Sars-CoV infection

More about ACE2

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ACE Inhibitor Pathway
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Metabolism of Angiotensinogen to Angiotensins (Reactome)

Pathways from Reactome

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SARS-CoV-1 Infection(Reactome)
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SARS-CoV-2 Infection(Reactome)

List of featured pathways:

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