Portal:COVID-19/FeaturedPathways

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== SARS-CoV-2 Pathways ==
== SARS-CoV-2 Pathways ==
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{| style="margin: 10px; background-color:#AFDCDE"
+
{| style="margin: 10px; background-color:#ECFFFF "
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP4846|250px||SARS-CoV-2 and COVID-19 Pathway}}
|width=100px; cell padding=50px|{{#pwImage:Pathway:WP4846|250px||SARS-CoV-2 and COVID-19 Pathway}}
Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.
Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.
|width=100px|{{#pwImage:Pathway:WP4860|250px||Hijack of Ubiquitination by SARS-CoV-2}}
|width=100px|{{#pwImage:Pathway:WP4860|250px||Hijack of Ubiquitination by SARS-CoV-2}}
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SARS-CoV-2 includes a novel Orf10 that interacts with muliple members of the Cullin 2 ubiquitin ligase complex.
+
SARS-CoV-2 includes a novel Orf10 that interacts with multiple members of the Cullin 2 ubiquitin ligase complex.
|width=100px|{{#pwImage:Pathway:WP4868|250px||Type I Interferon Induction and Signaling During SARS-CoV-2 Infection}}
|width=100px|{{#pwImage:Pathway:WP4868|250px||Type I Interferon Induction and Signaling During SARS-CoV-2 Infection}}
The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.  
The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.  
|width=100px|{{#pwImage:Pathway:WP4927|250px||COVID-19, thrombosis and anticoagulation}}
|width=100px|{{#pwImage:Pathway:WP4927|250px||COVID-19, thrombosis and anticoagulation}}
|-
|-
-
|}
 
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{| style="margin: 10px; background-color:#AFDCDE"
 
|width=100px|{{#pwImage:Pathway:WP4876|250px||Activation of NLRP3 Inflammasome by SARS-CoV-2}}
|width=100px|{{#pwImage:Pathway:WP4876|250px||Activation of NLRP3 Inflammasome by SARS-CoV-2}}
Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.
Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.
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Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
|-
|-
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|}
 
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{| style="margin: 10px; background-color:#AFDCDE"
 
|width=100px|{{#pwImage:Pathway:WP4904|250px||LDLRAD4 pathway in COVID-19}}
|width=100px|{{#pwImage:Pathway:WP4904|250px||LDLRAD4 pathway in COVID-19}}
|width=100px|{{#pwImage:Pathway:WP4936|250px||Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)}}
|width=100px|{{#pwImage:Pathway:WP4936|250px||Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)}}
 +
|width=100px|{{#pwImage:Pathway:WP4961|250px||STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens)}}
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|width=100px|{{#pwImage:Pathway:WP4969|250px||RAS and Bradykinin pathways in COVID-19 (Homo sapiens)}}
|-
|-
 +
|width=100px|{{#pwImage:Pathway:WP5027|250px||nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell}}
 +
|width=100px|{{#pwImage:Pathway:WP5038|250px||SARS-CoV-2 mitochondrial interactions}}
 +
|width=100px|{{#pwImage:Pathway:WP5039|250px||SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response}}
 +
|width=100px|{{#pwImage:Pathway:WP5063|250px||FOXP3 in COVID-19 (Homo sapiens)}}
 +
|-
 +
|width=100px|{{#pwImage:Pathway:WP5065|250px||SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)}}
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|width=100px|{{#pwImage:Pathway:WP5076|250px||Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens)}}
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|width=100px|{{#pwImage:Pathway:WP5115|250px||A Network Map of SARS-CoV-2 Signaling Pathway (Homo sapiens)}}
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|width=100px|{{#pwImage:Pathway:WP5116|250px||SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (Homo sapiens)}}
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|-
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|width=100px|{{#pwImage:Pathway:WP5145|250px||COVID-19 Structural coverage map (Homo sapiens)}}
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|width=100px|{{#pwImage:Pathway:WP5146|250px||Lung Pathology of COVID-19 (Homo sapiens)}}
 +
|width=100px|{{#pwImage:Pathway:WP5148|250px||Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical patwhay) (Homo sapiens)}}
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|width=100px|{{#pwImage:Pathway:WP5218|250px||Extrafollicular B cell activation by SARS-CoV-2 (Homo sapiens)}}
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|-
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|width=100px|{{#pwImage:Pathway:WP5255|250px||SARS-CoV-2 envelope lipid composition and human cell binding)}}
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|width=100px|{{#pwImage:Pathway:WP5414|250px||IDO metabolic pathway)}}
|}
|}
 +
== Other coronaviruses: MERS, SARS-CoV, etc ==
== Other coronaviruses: MERS, SARS-CoV, etc ==
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{| style="margin: 10px; background-color:#AFDCDE"
+
{| style="margin: 10px; background-color:#ECFFFF "
|width=100px|{{#pwImage:Pathway:WP4853|250px||Coronavirus lipid metabolism}}
|width=100px|{{#pwImage:Pathway:WP4853|250px||Coronavirus lipid metabolism}}
Lipid metabolism alternations that are related to infection by the corona virus.
Lipid metabolism alternations that are related to infection by the corona virus.
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|width=100px|{{#pwImage:Pathway:WP4912|250px||SARS coronavirus and innate immunity}}
|width=100px|{{#pwImage:Pathway:WP4912|250px||SARS coronavirus and innate immunity}}
|-
|-
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|}
 
-
{| style="margin: 10px; background-color:#AFDCDE"
 
|width=100px|{{#pwImage:Pathway:WP4861|250px||ER stress response in Coronavirus infection}}
|width=100px|{{#pwImage:Pathway:WP4861|250px||ER stress response in Coronavirus infection}}
|width=100px|{{#pwImage:Pathway:WP4799|250px||Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein}}
|width=100px|{{#pwImage:Pathway:WP4799|250px||Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein}}
|width=100px|{{#pwImage:Pathway:WP4877|250px||Host-pathogen interaction of human corona viruses - MAPK signaling}}
|width=100px|{{#pwImage:Pathway:WP4877|250px||Host-pathogen interaction of human corona viruses - MAPK signaling}}
|width=100px|{{#pwImage:Pathway:WP4880|250px||Host-pathogen interaction of human corona viruses - Interferon induction}}
|width=100px|{{#pwImage:Pathway:WP4880|250px||Host-pathogen interaction of human corona viruses - Interferon induction}}
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|-
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|width=100px|{{#pwImage:Pathway:WP4965|250px||Deregulation of the Renin Angiotensin system by Sars-CoV infection}}
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|-
|}
|}
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== More about ACE2 ==
== More about ACE2 ==
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{| style="margin: 10px; background-color:#AFDCDE"
+
{| style="margin: 10px; background-color:#ECFFFF "
|width=100px|{{#pwImage:Pathway:WP554|250px||ACE Inhibitor Pathway}}
|width=100px|{{#pwImage:Pathway:WP554|250px||ACE Inhibitor Pathway}}
|width=100px|{{#pwImage:Pathway:WP2729|250px||Metabolism of Angiotensinogen to Angiotensins (Reactome)}}
|width=100px|{{#pwImage:Pathway:WP2729|250px||Metabolism of Angiotensinogen to Angiotensins (Reactome)}}
|-
|-
|}
|}
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 +
== Pathways from Reactome ==
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 +
{| style="margin: 10px; background-color:#ECFFFF "
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|width=100px|{{#pwImage:Pathway:WP5020|250px||SARS-CoV-1 Infection(Reactome)}}
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|width=100px|{{#pwImage:Pathway:WP5021|250px||SARS-CoV-2 Infection(Reactome)}}
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|-
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|}
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 +
List of featured pathways:
 +
* [[Pathway:WP4846]]
 +
* [[Pathway:WP4860]]
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* [[Pathway:WP4868]]
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* [[Pathway:WP4927]]
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* [[Pathway:WP4876]]
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* [[Pathway:WP4883]]
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* [[Pathway:WP4891]]
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* [[Pathway:WP4884]]
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* [[Pathway:WP4904]]
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* [[Pathway:WP4936]]
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* [[Pathway:WP4853]]
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* [[Pathway:WP4863]]
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* [[Pathway:WP4864]]
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* [[Pathway:WP4912]]
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* [[Pathway:WP4861]]
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* [[Pathway:WP4799]]
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* [[Pathway:WP4877]]
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* [[Pathway:WP4880]]
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* [[Pathway:WP554]]
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* [[Pathway:WP2729]]
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* [[Pathway:WP5020]]
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* [[Pathway:WP5021]]
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* [[Pathway:WP4961]]
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* [[Pathway:WP4965]]
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* [[Pathway:WP4969]]
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* [[Pathway:WP5027]]
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* [[Pathway:WP5038]]
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* [[Pathway:WP5039]]

Current revision

Contents

SARS-CoV-2 Pathways

Image does not exist
SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

Image does not exist
Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with multiple members of the Cullin 2 ubiquitin ligase complex.

Image does not exist
Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

Image does not exist
COVID-19, thrombosis and anticoagulation
Image does not exist
Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

Image does not exist
SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target
Image does not exist
COVID-19 AOP

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

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nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

Image does not exist
LDLRAD4 pathway in COVID-19
Image does not exist
Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)
Image does not exist
STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens)
Image does not exist
RAS and Bradykinin pathways in COVID-19 (Homo sapiens)
Image does not exist
nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
Image does not exist
SARS-CoV-2 mitochondrial interactions
Image does not exist
SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response
Image does not exist
FOXP3 in COVID-19 (Homo sapiens)
Image does not exist
SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)
Image does not exist
Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens)
Image does not exist
A Network Map of SARS-CoV-2 Signaling Pathway (Homo sapiens)
Image does not exist
SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (Homo sapiens)
Image does not exist
COVID-19 Structural coverage map (Homo sapiens)
Image does not exist
Lung Pathology of COVID-19 (Homo sapiens)
Image does not exist
Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical patwhay) (Homo sapiens)
Image does not exist
Extrafollicular B cell activation by SARS-CoV-2 (Homo sapiens)
Image does not exist
SARS-CoV-2 envelope lipid composition and human cell binding)
Image does not exist
IDO metabolic pathway)


Other coronaviruses: MERS, SARS-CoV, etc

Image does not exist
Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

Image does not exist
Host-pathogen interaction of human corona viruses - autophagy
Image does not exist
Host-pathogen interaction of human corona viruses - apoptosis
Image does not exist
SARS coronavirus and innate immunity
Image does not exist
ER stress response in Coronavirus infection
Image does not exist
Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
Image does not exist
Host-pathogen interaction of human corona viruses - MAPK signaling
Image does not exist
Host-pathogen interaction of human corona viruses - Interferon induction
Image does not exist
Deregulation of the Renin Angiotensin system by Sars-CoV infection

More about ACE2

Image does not exist
ACE Inhibitor Pathway
Image does not exist
Metabolism of Angiotensinogen to Angiotensins (Reactome)

Pathways from Reactome

Image does not exist
SARS-CoV-1 Infection(Reactome)
Image does not exist
SARS-CoV-2 Infection(Reactome)

List of featured pathways:

Retrieved from "https://classic.wikipathways.org/index.php/Portal:COVID-19/FeaturedPathways"
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