Portal:COVID-19
From WikiPathways
Welcome to the COVID-19 Pathways Portal on WikiPathways
This special subset of disease pathways is being highlighted during the current COVID-19 crisis. This content is released under a CC0 waiver to be freely used, re-used and distributed. Let us know if you add a new pathway or want to recommend one for this collection.
Pathway Collection
All pathways tagged with "Curation: COVID-19" will be linked to this overview table, to help keep track of the relevant pathways.
Download all human COVID19 pathways
Contact us
Send questions about WikiPathways to the wikipathways-discuss mailing list.
How to add a pathway to the portal
The list of Featured Pathways is not static and can be updated at any time. If you know of a pathway that should be added, please contact the administrator.
- See our Help section for New Contributor QuickStart, Editor's Palette Guide and Guidelines for Contributors.
We are helping to coordinate an international effort to build and curate pathway models relevant to the COVID-19 pandemic. Review the resources below to see how you can get involved.
- growing collection of COVID-19 pathways. If you find or add a pathway at WikiPathways that should be included in this collection, please let us know.
- Published pathway figures related to COVID-19. Useful resource of previously published (but not modeled) pathways for direct translation as new pathways or to inform related pathway curation.
- Protein sequence alignments of SARS-CoV-2. Useful resource mapping SARS-CoV-2 proteins to those previously studied, including many solved structures.
- COVID-19 disease map initiative. An even broader community of pathway curators working with WikiPathways, Pathway Commons, Reactome, Cell Designer and more. Great community and set of resources, including repos, file shares, mailing list and Slack channel.
- Human Coronavirus protein identifiers and SARS-CoV-2 protein identifiers
- PubChem list of the COVID-19 Portal pathways
- KG COVID-19, a knowledge graph aggregating many sources as RDF
IMPORTANT: WikiPathways is dedicated to FAIR standards. All content at WikiPathways is freely available for use and reuse by a CC0 waiver.
Curation
There are curation tests being done, that check a number of drawing patterns, e.g. as agreed with the COVID-19 Disease Maps project. The reports can be found in this repository.
SARS-CoV-2 Pathways
|
Image does not exist SARS-CoV-2 and COVID-19 Pathway Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection. |
Image does not exist Hijack of Ubiquitination by SARS-CoV-2 SARS-CoV-2 includes a novel Orf10 that interacts with multiple members of the Cullin 2 ubiquitin ligase complex. |
Image does not exist Type I Interferon Induction and Signaling During SARS-CoV-2 Infection The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug. |
Image does not exist COVID-19, thrombosis and anticoagulation |
|
Image does not exist Activation of NLRP3 Inflammasome by SARS-CoV-2 Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome. |
Image does not exist SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target |
Image does not exist COVID-19 AOP Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways |
Image does not exist nsp9/nsp10-mediated SARS-CoV-2 pathogenesis Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis |
|
Image does not exist LDLRAD4 pathway in COVID-19 |
Image does not exist Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens) |
Image does not exist STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens) |
Image does not exist RAS and Bradykinin pathways in COVID-19 (Homo sapiens) |
|
Image does not exist nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell |
Image does not exist SARS-CoV-2 mitochondrial interactions |
Image does not exist SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response |
Image does not exist FOXP3 in COVID-19 (Homo sapiens) |
|
Image does not exist SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens) |
Image does not exist Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens) |
Image does not exist A Network Map of SARS-CoV-2 Signaling Pathway (Homo sapiens) |
Image does not exist SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (Homo sapiens) |
|
Image does not exist COVID-19 Structural coverage map (Homo sapiens) |
Image does not exist Lung Pathology of COVID-19 (Homo sapiens) |
Image does not exist Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical patwhay) (Homo sapiens) |
Image does not exist Extrafollicular B cell activation by SARS-CoV-2 (Homo sapiens) |
|
Image does not exist SARS-CoV-2 envelope lipid composition and human cell binding) |
Image does not exist IDO metabolic pathway) |
Other coronaviruses: MERS, SARS-CoV, etc
|
Image does not exist Coronavirus lipid metabolism Lipid metabolism alternations that are related to infection by the corona virus. |
Image does not exist Host-pathogen interaction of human corona viruses - autophagy |
Image does not exist Host-pathogen interaction of human corona viruses - apoptosis |
Image does not exist SARS coronavirus and innate immunity |
|
Image does not exist ER stress response in Coronavirus infection |
Image does not exist Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein |
Image does not exist Host-pathogen interaction of human corona viruses - MAPK signaling |
Image does not exist Host-pathogen interaction of human corona viruses - Interferon induction |
|
Image does not exist Deregulation of the Renin Angiotensin system by Sars-CoV infection |
More about ACE2
|
Image does not exist ACE Inhibitor Pathway |
Image does not exist Metabolism of Angiotensinogen to Angiotensins (Reactome) |
Pathways from Reactome
|
Image does not exist SARS-CoV-1 Infection(Reactome) |
Image does not exist SARS-CoV-2 Infection(Reactome) |
List of featured pathways:
- Pathway:WP4846
- Pathway:WP4860
- Pathway:WP4868
- Pathway:WP4927
- Pathway:WP4876
- Pathway:WP4883
- Pathway:WP4891
- Pathway:WP4884
- Pathway:WP4904
- Pathway:WP4936
- Pathway:WP4853
- Pathway:WP4863
- Pathway:WP4864
- Pathway:WP4912
- Pathway:WP4861
- Pathway:WP4799
- Pathway:WP4877
- Pathway:WP4880
- Pathway:WP5020
- Pathway:WP5021
- Pathway:WP4961
- Pathway:WP4965
- Pathway:WP4969
- Pathway:WP5027
- Pathway:WP5038
- Pathway:WP5039
- 26 Nov. 2021 A hackathon led to three new COVID-19 pathways
- 22 Jan. 2021 An index was added to the list of curation reports
- 28 Oct. 2020 A longer paper from the whole COVID Disease Pathways community is available on bioRxiv
- 09 Sept. 2020 This portal was created with content from the Disease portal created in March
- 02 Sept. 2020 COVID19 tag created and added to relevant pathways
- 05 May 2020 The COVID-19 Disease Maps project paper was published
- 23 March 2020 As part of the Disease portal, a collection of COVID-19 disease pathways was started
