Portal:CPTAC/Hallmarks

Sustaining proliferative signaling Ras signaling (Homo sapiens) Ras signaling	Evading growth suppressors Tumor suppressor activity of SMARCB1 (Homo sapiens) Tumor suppressor activity of SMARCB1	Activating invasion and metastasis TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition (Homo sapiens) TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition
Enabling replicative immortality Wnt signaling (Homo sapiens) Wnt signaling	Inducing angiogenesis VEGFA-VEGFR2 signaling (Homo sapiens) VEGFA-VEGFR2 signaling	Resisting cell death PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer (Homo sapiens) PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer
Deregulating cellular energetics Fatty acid beta-oxidation (Homo sapiens) Fatty acid beta-oxidation	Genome instability and mutation DNA damage response (Homo sapiens) DNA damage response	Tumor promoting inflammation Cytokines and inflammatory response (Homo sapiens) Cytokines and inflammatory response
Avoiding immune destruction Interferon type I signaling (Homo sapiens) Interferon type I signaling	Therapeutics Fluoropyrimidine activity (Homo sapiens) Fluoropyrimidine activity