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Each month there are new pathways reviewed and approved for the official release of WikiPathways. See the Download Page to access the full collection.


January 2023

Response to acute ibuprofen exposure (Daphnia magna)
Estrogen metabolism (Homo sapiens)
Ganglio series sphingolipid metabolism (Homo sapiens)
Lacto series sphingolipid metabolism (Homo sapiens)
Glucocorticoid biosynthesis (Homo sapiens)
Lipid remodeling (Anopheles gambiae)
Glycosphingolipid metabolism (Homo sapiens)
Steroid hormone precursor biosynthesis (Homo sapiens)
TROP2 regulatory signaling (Homo sapiens)
Neolacto series sphingolipid metabolism (Homo sapiens)
Mineralocorticoid biosynthesis (Homo sapiens)

December 2022

Extrafollicular and follicular B cell activation by SARS-CoV-2 (Homo sapiens)

November 2022

T cell modulation in pancreatic cancer (Homo sapiens)
Arachidonic acid (AA, ARA) oxylipin metabolism (Homo sapiens)
Markers of kidney cell lineage (Homo sapiens)
Comprehensive IL-17A signaling pathway (Mus musculus)
Cell interactions of the pancreatic cancer microenvironment (Homo sapiens)
17q12 copy number variation syndrome (Homo sapiens)
Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins (Homo sapiens)
Sildenafil treatment (Homo sapiens)

October 2022

Chronic hyperglycemia impairment of neuron function (Homo sapiens)
Serotonin reuptake inhibitor response (Daphnia magna)
Endothelial cell senescence (Homo sapiens)
Ether lipid biosynthesis (Homo sapiens)
Frustrated phagocytosis leading to malignant pleural mesothelioma (Homo sapiens)
Immune infiltration in pancreatic cancer (Homo sapiens)

September 2022

Triacylglyceride synthesis (Gallus gallus)

August 2022

Hippocampal synaptogenesis and neurogenesis (Homo sapiens)
Arsenic metabolism and reactive oxygen species generation (Homo sapiens)
Bardet-Biedl syndrome (Homo sapiens)
Estradiol regulation in Porto-Sinusoidal Vascular Disease (Homo sapiens)
Cholestasis (Homo sapiens)
Neurogenesis regulation in the olfactory epithelium (Homo sapiens)
Genetic causes of PSVD/INCPH (Homo sapiens)
Bacterial ceramide synthesis (Caulobacter vibrioides)
LDL- influence on CD14 and TLR4 (Homo sapiens)
Effect of intestinal microbiome on anticoagulant response of Vitamin K antagonists (Homo sapiens)
Farnesyl to CoQ10 metabolism (Homo sapiens)

July 2022

Lac-Phe pathway (Homo sapiens)
Lac-Phe pathway (Mus musculus)
Mitochondrial beta oxidation (Homo sapiens)

June 2022

2q11.2 copy number variation syndrome (Homo sapiens)

May 2022

Leucine, isoleucine and valine metabolism (Homo sapiens)
Metabolic reprogramming in pancreatic cancer (Homo sapiens)
2q13 copy number variation syndrome (Homo sapiens)
2q21.1 copy number variation syndrome (Homo sapiens)
2q37 copy number variation syndrome (Homo sapiens)

April 2022

Docosahexaenoic acid (DHA) oxylipin metabolism (Homo sapiens)
Metabolic pathway leukotriene (Homo sapiens)
DYRK1A (Homo sapiens)
Roles of ceramides in the development of insulin resistance (Homo sapiens)
Pro-survival signaling of neuroprotectin D1 (Homo sapiens)
Activation of Vitamin K-dependent proteins (Homo sapiens)
Retinol Metabolism (Homo sapiens)
Creatine Pathway (Homo sapiens)
ResolvinE1 and ResolvinD1 signaling pathways promoting inflammation resolution (Homo sapiens)
Modulation of the PI3K-Akt-mTOR signaling by bioactive sphingolipids (Homo sapiens)
Cholesterol synthesis disorders (Homo sapiens)
Synthesis of ceramides and 1-deoxyceramides (Homo sapiens)
N-Glycan biosynthesis (Sheep) (Ovis aries)
PtdIns(4,5)P2 in cytokinesis pathway (Homo sapiens)
Dravet syndrome (Homo sapiens)
Phospholipid biosynthesis (Saccharomyces cerevisiae)
Alstrom syndrome (Homo sapiens)
Clocked controlled autophagy in bone metabolism (Homo sapiens)
Glucose metabolism in triple-negative breast cancer cells (Homo sapiens)
Amino acid metabolism in triple-negative breast cancer cells (Homo sapiens)
Extrafollicular B cell activation by SARS-CoV-2 (Homo sapiens)

March 2022

Th17 cell differentiation pathway (Homo sapiens)
ALA oxylipin metabolism (Homo sapiens)
Linoleic acid oxylipin metabolism (Homo sapiens)
GDNF signaling (Homo sapiens)
Lipid metabolism in senescent cells (Homo sapiens)
Glyoxylate metabolism (Homo sapiens)
Hemesynthesis defects and porphyrias (Homo sapiens)
Disorders of galactose metabolism (Homo sapiens)
Ulcerative colitis signaling (Homo sapiens)
Disorders in ketone body synthesis (Homo sapiens)
Disorders of bile acid synthesis and biliary transport (Homo sapiens)
Disorders of fructose metabolism (Homo sapiens)
Biosynthesis and turnover of 1-deoxy-sphingoid bases (Homo sapiens)
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress in the mitochondria (Homo sapiens)
mRNA vaccine activation of Dendritic cell and induction of IFN-1 (Homo sapiens)
Copper metabolism (Homo sapiens)
Disorders in Ketolysis (Homo sapiens)
Inflammatory bowel disease signaling (Homo sapiens)

January 2022

Serotonin HTR1 group and FOS pathway (Homo sapiens)
BDNF pathway (Mus musculus)
Quercetin and Nf-kB / AP-1 induced apoptosis (Homo sapiens)
mRNA, protein, and metabolite inducation pathway by cyclosporin A (Homo sapiens)
Flavan-3-ol metabolic pathway (Homo sapiens)
miRNA degrading enzymes (Homo sapiens)
Measles virus infection (Homo sapiens)
Non-classical role of vitamin D (Homo sapiens)
SARS-CoV-2 replication organelle formation (Homo sapiens)

December 2021

GPR143 in melanocytes and retinal pigment epithelium cells (Homo sapiens)
Pentose phosphate pathway in senescent cells (Homo sapiens)
Salmonella virulence regulatory network (Escherichia coli)
NRP1-triggered signaling pathways in pancreatic cancer (Homo sapiens)

September 2021

Vasopressin-regulated water reabsorption (Homo sapiens)

August 2021

Angiotensin II receptor type 1 pathway (Homo sapiens)
Burn wound healing (Homo sapiens)
Burn Wound Healing (Mus musculus)
Malignant pleural mesothelioma (Homo sapiens)
Burn wound healing (Rattus norvegicus)
Kinin-Kallikrein pathway (Homo sapiens)
Network map of SARS-CoV-2 signaling pathway (Homo sapiens)
SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome (Homo sapiens)
Prostaglandin signaling (Homo sapiens)
Orexin receptor pathway (Homo sapiens)
Overview of proinflammatory and profibrotic mediators (Homo sapiens)
CCL18 signaling pathway (Homo sapiens)
Nucleotide excision repair in xeroderma pigmentosum (Homo sapiens)
Cohesin complex - Cornelia de Lange syndrome (Homo sapiens)
NIPBL role in DNA damage - Cornelia de Lange syndrome (Homo sapiens)
Sphingolipid metabolism in senescence (Homo sapiens)
Prostaglandin and leukotriene metabolism in senescence (Homo sapiens)
Fibrin complement receptor 3 signaling pathway (Mus musculus)

July 2021

Hypoxia-dependent self-renewal of myoblasts (Mus musculus)
Hypoxia-dependent proliferation of myoblasts (Mus musculus)
Hypoxia-dependent differentiation of myoblasts (Mus musculus)
Inclusion body myositis (Homo sapiens)
Familial hyperlipidemia type 1 (Homo sapiens)
Familial hyperlipidemia type 2 (Homo sapiens)
Familial hyperlipidemia type 3 (Homo sapiens)
Familial hyperlipidemia type 4 (Homo sapiens)
T-cell activation SARS-CoV-2 (Homo sapiens)
Congenital generalized lipodystrophy (CGL) (Homo sapiens)
Familial partial lipodystrophy (FPLD) (Homo sapiens)
Progeria-associated lipodystrophy (Homo sapiens)
Familial hyperlipidemia type 5 (Homo sapiens)
Acquired partial lipodystrophy / Barraquer-Simons syndrome (Homo sapiens)
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway (Homo sapiens)
Alzheimer's disease (Homo sapiens)
SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (Homo sapiens)
Meta pathway lipodystrophy, dyslipidemia and hyperlipidemia (Homo sapiens)
Interactions of natural killer cells in pancreatic cancer (Homo sapiens)

June 2021

Genes associated with the development of rheumatoid arthritis (Homo sapiens)
Neuroinflammation and glutamatergic signaling (Homo sapiens)
Complement system in neuronal development and plasticity (Homo sapiens)
Fatty acid biosynthesis (Caenorhabditis elegans)
Hepatocyte growth factor receptor signaling (Gallus gallus)
Hepatocyte growth factor receptor signaling (Pan troglodytes)
Hepatocyte growth factor receptor signaling (Canis familiaris)
S1P receptor signal transduction (Canis familiaris)

May 2021

Serine Metabolism (Homo sapiens)
Peptidoglycan cytoplasmic synthesis and recycling pathways (Escherichia coli)
FOXA2 pathway (Homo sapiens)
Modulators of TCR signaling and T cell activation (Homo sapiens)
Kallmann's Syndrome (Homo sapiens)
Fatty acid transporters (Homo sapiens)

April 2021

FOXP3 in COVID-19 (Homo sapiens)
SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)
Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens)

March 2021

Hair Follicle Development: Organogenesis - Part 2 of 3 (Homo sapiens)
Liver steatosis AOP (Homo sapiens)
nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell (Homo sapiens)
Kynurenine Pathway and links to Cellular Senescence (Homo sapiens)
NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence (Homo sapiens)
Nephrogenesis (Homo sapiens)
Development of ureteric collection system (Homo sapiens)
7-oxo-C and 7beta-HC pathways (Homo sapiens)

February 2021

Airway smooth muscle cell contraction (Homo sapiens)
SARS-CoV-2 mitochondrial interactions (Homo sapiens)
SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response (Homo sapiens)
Glycolysis in senescence (Homo sapiens)
TCA cycle in senescence (Homo sapiens)

January 2021

Mitochondrial fatty acid synthesis pathway (Homo sapiens)
Ethylmalonic Encephalopathy (Homo sapiens)
Biotin Metabolism (including IEMs) (Homo sapiens)
Riboflavin and CoQ disorders (Homo sapiens)

Prior Years

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